Abstract Background Microbial-driven decomposition of plant residues is integral to carbon sequestration in terrestrial ecosystems.Actinobacteria, one of the most widely distributed bacterial phyla in soils, are known for their ability offworld drum pads to degrade plant residues in vitro.However, their in situ importance and specific activity acro
Optimization of anti-CD19 CAR T cell production for treatment of patients with chronic lymphocytic leukemia
T cells expressing anti-CD19 chimeric antigen receptors (CARs) have activity against chronic lymphocytic leukemia (CLL), but complete response rates range from 18% to 29%, so improvement is needed.Peripheral blood mononuclear cells (PBMCs) of CLL patients often contain high levels of CLL cells that can interfere with CAR T cell production, and T
Genomic characterization of a newly established esophageal squamous cell carcinoma cell line from China and published esophageal squamous cell carcinoma cell lines
Abstract Background Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies and a major cause of cancer related death worldwide, especially in China.Cell lines are widely used disease models for basic medical research, however, well characterized ESCC cell models from China were seldom reported.Misidentifying and cross-c
BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements
Stable integration in the host genome renders murine leukemia virus (MLV)-derived vectors attractive tools for gene therapy.Adverse events in otherwise successful clinical trials caused by proto-oncogene activation due to vector integration hamper their application.MLV and MLV-based vectors integrate near strong enhancers, active promoters, and tra
Improving the W Coating Uniformity by a COMSOL Model-Based CVD Parameter Study for Denser Wf/W Composites
Tungsten strikketøy oppbevaring (W) has the unique combination of excellent thermal properties, low sputter yield, low hydrogen retention, and acceptable activation.Therefore, W is presently the main candidate for the first wall and armor material for future fusion devices.However, its intrinsic brittleness and its embrittlement during operation b